Last edited by Malashura
Thursday, November 12, 2020 | History

2 edition of Investigations on the urinary excretion of adrenal cortical steroids in man. found in the catalog.

Investigations on the urinary excretion of adrenal cortical steroids in man.

Mogens Sprechler

Investigations on the urinary excretion of adrenal cortical steroids in man.

  • 217 Want to read
  • 17 Currently reading

Published by E. Munksgaard in Copenhagen .
Written in English

    Subjects:
  • Adrenocortical hormones,
  • Steroid hormones,
  • Urine -- Analysis and pathology

  • Classifications
    LC ClassificationsQP801 H7 S6
    The Physical Object
    Pagination[various pagings]
    ID Numbers
    Open LibraryOL18119781M

    Some investigators have reported an increase in the urinary reducing steroids and no change in neutral ketosteroids after salicylate therapy. Others have reported a significant decrease in the urinary hydroxycorticosteroid excretion with a slight decrease in ketosteroid excretion in individuals who have been given large doses of. The adrenal cortex and the renin-angiotensin system of lower vertebrates / D.K.O. Chan and C.K Acute effect of captopril on urinary excretion of endothelin in normal Chinese subjects / H The role of the renin-angiotensin-aldosterone system in blood pressure control and sodium excretion in normal man \/ T.F.T. Antonios and G.A. MacGregor. IN THIS PAPER the results of an investigation of adrenal cortical activity in manicdepressive illness are reported. Two rapidly cycling manic-depressive patients were studied in the hospital through several cycles by daily clinical assessment of their psychological state, and by daily measurement of hour urinary hydroxycorticosteroid (OHCS) excretion.


Share this book
You might also like
U.S. policy toward China

U.S. policy toward China

The day of the dissonance

The day of the dissonance

Womans rights

Womans rights

Tarot.

Tarot.

Love is for tomorrow

Love is for tomorrow

Limas Red Hot Chilli

Limas Red Hot Chilli

Minutes of the meeting.

Minutes of the meeting.

Radioactivity in man

Radioactivity in man

Medical inquiries and observations

Medical inquiries and observations

Capture a shadow

Capture a shadow

Fees of examining surgeons, Bureau of Pensions.

Fees of examining surgeons, Bureau of Pensions.

Shklovsky

Shklovsky

Traditional Island Knitting

Traditional Island Knitting

[Paintings].

[Paintings].

Macmillan Language Arts Today 7

Macmillan Language Arts Today 7

Gentians

Gentians

Investigations on the urinary excretion of adrenal cortical steroids in man. by Mogens Sprechler Download PDF EPUB FB2

Excretion rates of noradrenaline, adrenaline, sodium, potassium and creatinine did not differ significantly between Mawson and Melbourne, nor did urine flow rates.

During the cold exposure significant increases occurred, to the same extent at Mawson as in Investigations on the urinary excretion of adrenal cortical steroids in man.

book, in urine flow rate and in all measured urinary constituents except by: 1. Author(s): Sprechler,Mogens Title(s): Investigations on the urinary excretion of adrenal cortical steroids in man.

Country of Publication: Denmark Publisher: Copenhagen, Munksgaard, Description: 1 v. (various pagings) ill. Language: English Other Subject(s): Hormones / Steroid Notes: Five reports, reprinted from Acta endocrinologica.

At the time of evaluation the diagnosis of Cushing's syndrome could not be made in these patients since they had normal values for the following studies; basal urinary ketogenic steroid excretion, adrenal cortical suppression with dexamethasone, and plasma 17 Cited by:   Urinary Excretion of Parathyroid Hormone in Man: Effects of Calcium Loads, Protein-Free Diets, Adrenal Cortical Steroids and Neoplastic Disease 1.

LEONARD P. ELIEL. 1 Cancer Section of the Oklahoma Medical Research Institute and the Department of Medicine, " This investigation was supported by USPHS Research Grants C and CA(01 Cited by: Urinary Free Cortisol Excretion.

For many years, the diagnosis of Cushing syndrome was based on the measurement of urinary metabolites of cortisol (hour urinary hydroxycorticosteroid or oxogenic steroid excretion, depending on the method used). However, the sensitivity and specificity of these methods are poor, and most centers have.

Click on the article title to read more. Urinary free Cortisol (UFC) excretion was determined in 60 depressed inpatients and in 35 psychiatric inpatients with other disorders.

UFC determination is a simple and informative indicator of adrenal cortical activation and its application to psychoendocrine studies is recommended. A preliminary investigation of steroid excretion in. The present investigation was undertaken to measure gastric secretion in patients with Cushing's syndrome before and after treatment by subtotal adrenalectomy, and to discover whether, in these or in other people, there was any correlation between the level of gastric secretion and the urinary excretion of adrenal cortical steroids.

Measurement of urinary excretion of corticosteroid (any steroid hormone produced by the adrenal cortex) metabolites has been used to evaluate adrenal function for many years.

However, measurement of urinary cortisol excretion is more sensitive for the diagnosis of hypercortisolism and has largely supplanted the older assays. COVID campus closures: see options for getting or retaining Remote Access to subscribed content. Excretion of steroidal substances by the adrenal cortex in various diseases.

J Clin Endocrinol Metab. Nov; 11 (11)– GOLDMAN R, BASSETT SH. Diurnal variation in the urinary excretion of neutral lipid-soluble reducing steroids in congestive cardiac failure and cirrhosis of the liver with ascites.

Effects of Eight-Hour Intravenous Infusions of ACTH and the Adrenocortical Steroids in Normal Man. Basal Gastric Secretion, and Plasma and Urinary Pepsinogen 1, 2 B.

Hirschowitz, D. Streeten, 3 J. London, and H. Pollard. Urinary steroid excretions were studied in normal postmenopausal women (age limits 55–75 yr) taking part in a prospective study on breast cancer, designed by de Waard in the Netherlands (“Kamper-foelie or Honeysuckle” project).

Out of the women in this study, a small control group was selected, representative of the normal population. Three abnormal patterns of urinary steroid excretion were identified in patients with adrenocortical carcinoma at presentation and/or follow-up of residual disease: (1) hypersecretion in multiple.

Honour has 45 years of experience in analyzing steroids mainly by gas chromatography and mass spectrometry and applying these results to the investigation of patients with endocrine disorders.

His work has included the diagnosis of inherited disorders of blood pressure, sex determination, infertility, osteoporosis, and salt balance in the body.

Urinary steroid excretion was increased before resection of the primary tumor. In our patient, ACC metastases did not appear to produce excess amounts of steroids, but this may be related to the relatively small tumor volume at that time.

FIG. Section showing a small focus of a lymph node metastasis of ACC. Tumor. Simultaneous estimation of urinary steroids by semi-automated gas chromatography. Investigation of neo-natal infants and children with abnormal steroid synthesis.

Clin Chim Acta. Jun 1; 69 (2)– Abraham GE, Chakmakjian ZH. Serum steroid levels during the menstrual cycle in a bilaterally adrenalectomized woman. J Clin Endocrinol Metab.

THE ROLE of the adrenal cortex in promoting the formation of carbohydrate from protein sources has been demonstrated in experimental animals (1).

Normal Urinary Excretion and the Clinical. URINARY EXCRETION OF ADRENAL CORTICAL STEROIDS URINARY EXCRETION OF ADRENAL CORTICAL STEROIDS Venning, Eleanor H.; Browne, J. It has become apparent in recent years, through the work of many investigators, that the adrenal cortex has a variety of functions.

The substances so far derived from it may be roughly divided into three groups: (1). prednisone on adrenal steroid hormone production was examined using hour urinary steroid hormone profiling. Five women, who were chronically taking low-dose prednisone, were tested, and the relevant literature was reviewed.

As expected, adrenal glucocorticoid production, measured by urinary. Urinary Cortisol excretion determined by competitive protein-binding radioassay: a test of adrenal cortical function.

Journal of Laboratory and Clinical Medic. The adrenal cortex is believed to secrete steroids with androgenic and estrogenic activity or precursors which are transformed to androgenic or estrogenic substances outside the adrenal cortex.

Howard and Migeon () in Chapter 5 of Part 1 of this Volume have reviewed the evidence for the secretion of sex hormones by the normal adrenal cortex. urinary steroid profiling which is a multi­ component analysis using gas chromatography and mass spectrometry (GC-MS) designed to reveal, at the biochemical level, defects in metabolism largely of adrenal cortical steroids.

The gonadal steroid metabolites are nearly always present at lower levels than the adrenal. Results of mass spectrometry-based urinary steroid profiling were compared to healthy controls and 56 patients with overt adrenal Cushing’s syndrome (CUSH), using a sex- and age-adjusted.

Acetylsalicylic acid (ASA) is efficacious, as are adrenocortical steroids, in the treatment of acute rheumatic fever. 1,2 Similarity in the symptomatic relief produced by ASA and by cortisone in arthritic patients suggests a similarity of action.

3,4 That some interrelation may exist has been proposed by several investigators. 5 Prolonged salicylate ingestion has been reported to induce a mild. disease but was normal with respect to adrenal cortical function.

The male patient had clinical evidence of hypoleydigism, a high excretion of follicle-stimulating hormone in the urine, a high ketosteroid excretion, and, as demonstrated at exploration at the age of 8, bilateral rudimentary testes. Thus, the evidence for lack of testicular.

the adrenal cortex was indeed the source of these urinary estrogens or their precursors. This type of investigation does not prove that the normal adrenal cortex has anything to do with sterility in the absence of adrenal disease but it does show that normal adrenal cortical tissue is a potential source of.

The analysis of h excretion profiles of urinary steroids in 18 patients suffering from Cushing's syndrome or adrenocortical tumors revealed typical patterns when compared to 37 healthy control persons, 24 patients with obesity, and 6 patients with hirsutism.

The validation of eight criteria — increased excretion of free cortisol, 6β-hydroxycortisol, 20α-dihydrocortisol, 11β. The urinary ketosteroid excretion after corti-cotiophin provides a more valuable indication of adrenal cortical function and many of the current tests rely on this estimation.

In males, however, the ketosteroids are only partly derived from the adrenal cortex, andsometimesa clearly defined rise after corticotrophin is not obtained even in. INCREASES IN ADRENAL CORTICAL FUNCTION ON URINARY ALPHAKETOLIC STEROID METABOLITES F.

Dohan,Irmgard Landolt, Walter Applin ' This investigation was supported in part by research grant H from the National Heart Institute, us exposed the urinary steroids to pH 1.

diurnal variation in the urinary excretion of neutral lipid-soluble reducing steroids in congestive cardiac failure and cirrhosis of the liver with ascites 1, 2 Ralph Goldman and Samuel H.

Bassett Metabolic Unit, General Medical Research Program, Veterans Administration Center, Los Angeles. adrenal function, the first part being a water load excretion test. If there is delayed diuresis in this part, thesecondprocedureis adoptedanddepends onthreefeaturesofAddison'sdisease.

First, there is retention of urea in the plasma and a poor urinary output of urea; secondly, there is a low plasma chloride and an increased urinary output. the adrenal cortex was under maximal stimulation intheseinfants. Theseauthors,however,collected urine for only 12 hours 'in most ofthe cases' and calculated the hour excretion of OHCS on this basis.

The known diurnal variation in the urinary excretion of cortisol metabolites, with maximal excretion in the early hours ofthe day. The effect of ACTH and pathological increases in adrenal cortical function on urinary alpha-ketolic steroid metabolites.

DOHAN FC, TOUCHSTONE JC, RICHARDSON EM. and desoxy C2, steroids is manifest on stimulation of the adrenal cortex (Fig. There is also evidence fromthe increased excretion of ketosteroids to show that the C19 steroids are produced as a result of this stimulation, and previously urinary.

Urinary excretion of adrenal cortical steroids. (PMID) Abstract Citations; Related Articles; Data; BioEntities; External Links ' ' VENNING EH, ' ' BROWNE JS Annals of the New York Academy of Sciences [01 Jun50(Art.

6)] Type: Journal. increasing urinary excretion of potassium ions adrenal cortex, and ovaries metabolically converted to testosteron enad other androgens The common substrate from which all adrenal steroids are produced.

Cholesterol _____ is responsible for epinephrine production. Cortisol. specific activity, and thereafter purified in the same man-ner as in the urinary excretion measurements. Using standard isotopic dilution equations, we determined the hour secretion rate from the 'H to "4C ratio of the purified sample.

Assay of adrenal tissue. The adrenal tissue was kept frozen until assayed by a modification of the double iso. Abstract. The adrenal cortex is the only organ capable of producing aldosterone in man and other mammalian species.

In adrenalectomized patients, sheep, and dogs, as well as in some (but not all) patients with Addison’s disease, aldosterone plasma concentrations and secretion rates or the urinary excretion of aldosterone metabolites have been found to be either unmeasurably low or within the.

The hydroxycortisol (OHF) and oxocortisol (oxoF) are secreted by the adrenal cortex. 1,2 These hybrid C–oxygenated steroids are different from the other steroids produced in the adrenal cortex because they combine structural characteristics of the products secreted by the fasciculata and glomerulosa zones.

Thus, they are hydroxylated at car a feature of fasciculata. Hormone produced by the adrenal cortex that acts on the distal convoluted tubule, which increases water reabsorbed into the bloodstream.

Antidiuretic Hormone (ADH) Hormone released from the posterior pituitary gland to increase the amount of water returned to .Adrenal cortical control of renal function The control of renal function by the adrenal cortex can best be considered separately for steroids with predominately carbohydrate-regulating activity, e.g., cortisol, and for those with sodium-retaining activity, e.g., aldosterone.' In addition, progesterone may act as an aldosterone antagonist [Adrenal steroids possessing activities of sex hormones.

Androgenic. Estrogenic. Progesterone. Adrenal steroids which affect protein, carbohydrate and uric acid metabolism and which also produce important hematologic changes. Adrenal steroids which act mainly on sodium, potassium and chloride metabolism and, thus, on water metabolism as well.